In vitro fertilization is clearly a successful technology, although it remains experimental; the safety and efficacy of new methods and reagents can be difficult to assess. And “traditional ...

The author describes pronuclear transfer, a type of mitochondrial donation, which was made available to women with mitochondrial DNA disease in a reproductive care pathway implemented in Newcastle, ...

Children born to women who carry pathogenic variants in mitochondrial DNA (mtDNA) are at risk for a range of clinical syndromes collectively known as mtDNA disease. Mitochondrial donation by pronuc ...

Audio Interview from the New England Journal of Medicine — Interview with I. Glenn Cohen on the professional implications of the use of artificial-intelligence–based monitoring systems in ...

Explore this issue of The New England Journal of Medicine (Vol. 392 No. 23).

Use of some antifungal pesticides may select for resistant fungi in the environment, which can then endanger human health. Coordinated regulatory processes in this area are important.

Measurable residual disease (MRD) is a major prognostic factor in newly diagnosed multiple myeloma. An assessment of an MRD-guided consolidation strategy in patients who are eligible for autologous ...

Patients who have cutaneous squamous-cell carcinoma with high-risk features are at risk for recurrence after definitive local therapy. The benefit of systemic adjuvant therapy options has not been ...

Overweight and obesity represent addressable proximal drivers of chronic disease.1 The prevalence of overweight and obesity is increasing around the world; by 2050, projections indicate that more t ...

Explore Interactive Medical Case articles from The New England Journal of Medicine ...

In this editorial, the authors describe the foundations of an N-of-1 gene-editing study to treat an infant with a urea-cycle disorder.

Among patients with COPD, those with persistent or newly formed mucus plugs at 5-year follow-up had a greater decrease in lung function than those with resolved or no mucus plugs.