Objective SLE is a multisystem autoimmune disease characterised by chronic inflammation and progressive organ damage, ...

Formidable impediments stand in the way of treatment development for lupus. These include the unwieldy size of current trials, international competition for scarce patients, complex outcome measures ...

Objectives To evaluate the Systemic Lupus International Collaborating Clinics-Frailty Index (SLICC-FI) as a predictor of hospitalisations in patients with SLE from a Latin American cohort.Methods ...

Objective The association of immune-mediated thrombotic thrombocytopenic purpura (iTTP) and SLE was previously described, but patients with iTTP with coexistent SLE remain poorly characterised.

Objective This study aims to evaluate the diagnostic performance of the digital liquid chip method (DLCM) compared with indirect immunofluorescence (IIF) and chemiluminescent immunoassay (CLIA) for ...

Objective Our primary objective was to estimate an updated prevalence of SLE in France in 2020. We also explore the sociodemographic characteristics of patients with SLE, the social and spatial ...

Background Endotoxaemia without infection in lupus is mentioned with the inconclusive clinical importance.Methods With endotoxaemia and lupus activity (Systemic Lupus Erythematosus Disease Activity ...

Objectives To assess brain grey matter alterations in patients with SLE and their correlation with neuropsychological testing using synthetic MRI (SyMRI).Methods This prospective study enrolled ...

Objective Systemic lupus erythematosus (SLE) disproportionately affects women and often develops during their reproductive years. Research suggests that some women who receive cyclophosphamide as ...

The unpredictable nature of the SLE disease activity makes its management particularly challenging. Current treatment options for SLE focus on managing the inflammatory status, decreasing the symptoms ...

Background The interaction between fine particulate matter (PM2.5) and genetic factors can lead to epigenetic modifications, potentially increasing the risk of SLE development. However, the impact of ...