Leading cardiologists discuss PARADIGM-HF, a trial of angiotensinneprilysin inhibition versus enalapril in advanced heart failure.

Explore the current issue of The New England Journal of Medicine (Vol. 393 No. 4).

The discovery of a highly efficacious option for preexposure prophylaxis that requires only twice-yearly administration has led to the question of whether a vaccine is still needed to end the HIV ...

Patients with small-cell lung cancer that relapses after platinum chemotherapy have few effective treatment options. A new phase 3 trial shows improved survival and symptom control with the delta ...

To the Editor: Frangoul and colleagues (Jan. 21 issue)1 report striking results with gene editing for sickle cell disease and transfusion-dependent β-thalassemia with the use of the BCL11A ...

The authors describe the implications of the Affordable Care Act for safety-net health systems and how hospital-based safety-net care systems are responding to health care reform.

In vitro fertilization is clearly a successful technology, although it remains experimental; the safety and efficacy of new methods and reagents can be difficult to assess. And “traditional ...

A 4-month-old boy presented with a progressively worsening rash on his abdomen, diaper area, limbs, face, and scalp. A biopsy was performed, and a diagnosis of zinc deficiency–associated ...

The rate of unintended pregnancy in the United States increased slightly between 2001 and 2008 and is higher than that in many other industrialized countries. National trends have not been reported ...

Patients with microsatellite-instability–high (MSI-H) or mismatch-repair–deficient (dMMR) metastatic colorectal cancer have poor outcomes with standard chemotherapy with or without targeted ...

Explore a collection of articles and other resources on the Coronavirus (Covid-19) outbreak, including clinical reports, management guidelines, and commentary.

This feature about a women with AF triggered by sepsis offers a case vignette accompanied by two essays, one supporting oral anticoagulant therapy after discharge and the other recommending no ...