Leading cardiologists discuss PARADIGM-HF, a trial of angiotensinneprilysin inhibition versus enalapril in advanced heart failure.

Explore the current issue of The New England Journal of Medicine (Vol. 393 No. 4).

Patients with small-cell lung cancer that relapses after platinum chemotherapy have few effective treatment options. A new phase 3 trial shows improved survival and symptom control with the delta ...

In vitro fertilization is clearly a successful technology, although it remains experimental; the safety and efficacy of new methods and reagents can be difficult to assess. And “traditional ...

The authors describe the implications of the Affordable Care Act for safety-net health systems and how hospital-based safety-net care systems are responding to health care reform.

To the Editor: Frangoul and colleagues (Jan. 21 issue)1 report striking results with gene editing for sickle cell disease and transfusion-dependent β-thalassemia with the use of the BCL11A ...

Sarcoidosis, a granulomatous disease that affects the lungs and other organs, has a variable course. Although spontaneous resolution of sarcoidosis occurs in some patients, half the patients with s ...

Between 1999 and 2009 in the United Kingdom, 82,429 men between 50 and 69 years of age underwent prostate-specific antigen (PSA) testing as part of the Prostate Testing for Cancer and Treatment (Pr ...

The rate of unintended pregnancy in the United States increased slightly between 2001 and 2008 and is higher than that in many other industrialized countries. National trends have not been reported ...

Children born to women who carry pathogenic variants in mitochondrial DNA (mtDNA) are at risk for a range of clinical syndromes collectively known as mtDNA disease. Mitochondrial donation by pronuc ...

Explore a collection of articles and other resources on the Coronavirus (Covid-19) outbreak, including clinical reports, management guidelines, and commentary.

After decades of undergoing epidemiologic study, prostate cancer remains an enigmatic disease; the only established risk factors are older age, family history of prostate cancer, and African ancest ...