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铜绿假单胞菌组氨醇脱氢酶中金属离子依赖性功能 ...
这项研究揭开了铜绿假单胞菌组氨醇脱氢酶 (Histidinol dehydrogenase, HisD)的神秘面纱——这种负责催化L-组氨醇转化为L-组氨酸的终极步骤的酶,在细菌代谢中扮演着关键角色。通过X射线晶体学这把"分子显微镜",科研人员捕捉到酶蛋白结构的精妙变化:新发现的底物结合口袋如同隐藏的密室,而意外 ...
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